Background：The autosomal dominant cerebellar ataxias （ADCA） are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups： ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia （SCA） 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration （SCA7）, and ADCAIII often referred to as the `pure' cerebellar syndrome （SCA5）, are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions.
仕様
Synonyms：alternative ataxin1,Ataxin-1,ATX1,ATX1,Atxn1,D6S504E,OTTHUMP00000016065,SCA1,Spinocerebellar ataxia type 1 protein
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.4mg/mL
Immunogen：Recombinant protein of human ATXN1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：P54253
Isotype：IgG
Research Areas：Epigenetics and Nuclear Signaling, Neuroscience
