Background：AKIP （AURKA-interacting protein）, also known as AURKAIP1 （aurora kinase A interacting protein 1） or AIP, is a 199 amino acid protein that localizes to the nucleus and is ubiquitously expressed, with highest levels present in testis, heart and skeletal muscle. Interacting specifically with ARK-1 （aurora kinase 1）, AKIP functions to induce the proteasomal-dependent degradation of ARK-1, thereby acting as a negative regulator of ARK-1 activity. AKIP is encoded by a gene which maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8％ of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson's disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
仕様
Synonyms：28S ribosomal protein S38,AIP,AKIP,AURKA interacting protein,AURKA-interacting protein,AURKAIP 1,Aurkaip1,Aurora A kinase interacting protein,Aurora kinase A interacting protein 1,Aurora kinase A-interacting protein,FLJ20608,mitochondrial,MRP-S38
Host：Rabbit
Reactivity：Human
Applications：WB,ELISA
Concentration：0.2mg/mL
Immunogen：Recombinant protein of human AURKAIP1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
