Background：One member of the STAT family, Stat3, participates in a wide range of biological processes including nephrogenesis, gliogenesis, hepatogenesis, T cell proliferation, inflammation and oncogenesis. Many of these responses are triggered by the IL-6 family of cytokines, which transduce their vital signals through a common gp130 receptor chain . A novel Stat3-Interacting Protein, StIP1, contains 12 WD40 repeats, which mediate protein-protein interactions . StIP1 exhibits an affinity for members of the JNK family and may play a specific role in regulating Stat3 activation. Overexpression of StIP1 blocks Stat3 activation, nuclear translocation and Stat3-dependent induction of a reporter gene, suggesting that StIP1 regulates the ligand-dependent activation of Stat3, probably by serving as a scaffold protein that promotes the interaction between JNK and the Stat3 substrate.
仕様
Synonyms：AU023723,Elongation protein 2 homolog （S. cerevisiae）,Elongator acetyltransferase complex subunit 2,Elongator complex protein 2,elongator protein 2,ELP2,ELP2,Epl2,FLJ10879,SHINC 2,SHINC-2,SHINC2,signal transducer and activator of transcription 3 interacting protein 1,signal transducer and activator of transcription interacting protein 1,STAT3 interacting protein 1,Stat3 interacting protein,STAT3-interacting protein 1,STATIP 1,STATIP1,STATIP1 protein,StIP,StIP1
Host：Rabbit
Reactivity：Human,Rat
Applications：IHC,ELISA
Concentration：0.4mg/mL
Immunogen：Recombinant protein of human ELP2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：Q6IA86
Isotype：IgG
Research Areas：Epigenetics and Nuclear Signaling, Signal transduction
