Background：The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms （with preferential cellular localization） resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG （CUG） and downstream AUG codons.
仕様
Synonyms：Oncogene PIM 1,Oncogene PIM1,PIM 1,pim 1 kinase 44 kDa isoform,Pim 1 kinase,pim 1 oncogene （proviral integration site 1）,Pim 1 oncogene,PIM,PIM1,pim1 kinase 44 kDa isoform,PIM1,Pim2,PIM3,Proto oncogene serine/threonine protein kinase Pim 1,Proto-oncogene serine/threonine-protein kinase Pim-1,Proviral integration site 1,Proviral integration site 2
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.3mg/mL
Immunogen：Recombinant protein of human PIM1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：P11309
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Signal transduction, Stem cells
