Background：Docking protein 4is aproteinthat in humans is encoded by theDOK4gene. Dok-4 is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis.
仕様
Synonyms：docking protein 4,Downstream of tyrosine kinase 4,FLJ10488,insulin receptor substrate 5,IRS5
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC,ELISA
Concentration：0.5mg/mL
Immunogen：Recombinant protein of human DOK4
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：Q8TEW6
Isotype：IgG
Research Areas：Cancer, Neuroscience, Signal transduction
