Background：This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha （tumor necrosis factor alpha） -induced NF-kB （nuclear factor kB） signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 （MDM2）, MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
仕様
Synonyms：41 kDa ubiquitin specific protease,41 kDa ubiquitin-specific protease,Deubiquitinating enzyme 2,Ubiquitin carboxyl terminal hydrolase 2,Ubiquitin carboxyl-terminal hydrolase 2,ubiquitin specific peptidase 2,Ubiquitin specific processing protease 2,Ubiquitin specific protease 12,Ubiquitin specific protease 9,Ubiquitin specific protease,41kD,Ubiquitin thioesterase 2,Ubiquitin thiolesterase 2,Ubiquitin-specific-processing protease 2,Ubiquitin-specific-processing protease testis,UBP-t,UBP2,UBP41,USP2,USP9
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.3mg/mL
Immunogen：Recombinant protein of human USP2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：O75604
Isotype：IgG
Research Areas：Cell Biology, Epigenetics and Nuclear Signaling
