Background：CARF （calcium-response factor）, also known as ALS2CR8 （amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein） or NYD-SP24, is a 725 amino acid nuclear protein. Expressed in a wide variety of tissues with highest expression in the hippocampus, CARF is thought to be a transcription factor that associates with the p53 tumor suppression pathway. CARF cooperates, co-localizes and is co-regulated with ARF, an ADP-ribosylation factor, and, through this interaction, helps to mediate ARF-p53-induced apoptotic signaling. This apoptotic pathway is implicated in cell cycle control, proper cellular development, response to DNA damage and the aging process, suggesting that CARF participates in various events throughout the cell.
仕様
Synonyms：Amyotrophic lateral sclerosis 2 （juvenile） chromosome region candidate 8,Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein,Calcium response factor,Calcium-response factor,Calcium-responsive transcription factor,CaRF,CARTF,Testis development protein NYD SP24,Testis development protein NYD-SP24
Host：Rabbit
Reactivity：Human
Applications：WB,ELISA
Concentration：0.3mg/mL
Immunogen：Recombinant protein of human CARF
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：200-1：1000
Swissprot：Q8N187
Isotype：IgG
Research Areas：Cell Biology, Epigenetics and Nuclear Signaling
