Background：The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor （TRAF） protein family and contains a meprin and TRAF homology （MATH） domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor （TNF） receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have been characterized.
