Background：PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells. Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association.
仕様
Synonyms：DKFZp686P01248,FLJ36156,HILI 2,HILI2,HIWI 2,HIWI2,Miwi 2 protein,Miwi2,PIWI,Piwi like 2,Piwi like 4 （Drosophila）,Piwi like 4,Piwi like protein 4,PIWI like protein,Piwi like RNA mediated gene silencing 4,Piwi-like protein 4,PIWIL 4,Piwil4,PIWL4
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,ELISA
Concentration：0.4mg/mL
Immunogen：Recombinant protein of human PIWIL4
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：500-1：2000
Swissprot：Q7Z3Z4
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
