Background：This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames （ORFs）, RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG （CUG） start codon, have been reported for this gene. Increased expression of this gene is associated with hepatocellular carcinomas.
仕様
Synonyms：AA407948,Edr,Embryonal carcinoma differentiation regulated,Embryonal carcinoma differentiation-regulated protein,HB 1,HB1,KIAA1051,Mammalian retrotransposon-derived protein 2,Mar2,Mart2,MEF3 like 1,MEF3-like protein 1,MEF3L,MEF3L1,MyEF 3,Myelin expression factor 3-like protein 1,Paternally expressed 10,Paternally expressed gene 10 ORF1,Paternally expressed gene 10 protein,Peg10,PEG10 protein,PEG10,Putative uncharacterized protein PEG10,Retrotransposon gag domain containing 3,Retrotransposon gag domain-containing protein 3,Retrotransposon-derived gag-like polyprotein,Retrotransposon-derived protein PEG10,RGAG3,Ty3/Gypsy-like protein
Host：Rabbit
Reactivity：Human
Applications：WB,ELISA
Concentration：0.2mg/mL
Immunogen：Recombinant protein of human PEG10
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：200-1：1000
Swissprot：Q86TG7
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Stem cells
