Background：This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 （EEC3）; split-hand/foot malformation 4 （SHFM4）; ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome （acro-dermato-ungual-lacrimal-tooth）; limb-mammary syndrome; Rap-Hodgkin syndrome （RHS）; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins.
仕様
Synonyms：AIS,Amplified in squamous cell carcinoma,B（p51A）,B（p51B）,Chronic ulcerative stomatitis protein,CUSP,DN p63 alpha 1,DNp63,EEC3,id：ibd3516,Keratinocyte transcription factor,Keratinocyte transcription factor KET,KET,LMS,MGC115972,MGC192897,NBP,OFC8,OTTHUMP00000209732,OTTHUMP00000209733,OTTHUMP00000209734,OTTHUMP00000209735,OTTHUMP00000209737,OTTHUMP00000209738,OTTHUMP00000209739,OTTHUMP00000209740,OTTHUMP00000209741,OTTHUMP00000209742,OTTHUMP00000209743,OTTHUMP00000209744,p40,p51,P51/P63,p53-related protein p63,p53CP,p63,P63,p73H,p73L,RHS,SHFM4,TAp63alpha,TP53CP,TP53L,TP63,TP73L,Transformation related protein 63,Transformation-related protein 63,Trp53rp1,Trp63,Tumor protein 63,Tumor protein p53-competing protein,Tumor protein p53-like,Tumor protein p63,Tumor protein p63 deltaN isoform delta,Tumor protein p73,Tumor protein p73-like
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,ELISA
Concentration：0.3mg/mL
Immunogen：Recombinant protein of human TP63
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：200-1：1000
Swissprot：Q9H3D4
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling
