Background：CDKN2AIP （CDKN2A-interacting protein）, also known as CARF, is a 580 amino acid protein that activates p53 via p14 ARF （alternate reading frame）-dependent and independent pathways. CDKN2AIP-dependent activation of p53, a protein that up-regulates growth arrest and apoptosis-related genes in response to stress signals, leads to an enhancement of p53 function. Expression levels of CDKN2AIP and p53 show an inverse relationship that is caused by a negative-feedback control via a proteasome-mediated degradation pathway. CDKN2AIP is expressed ubiquitously across tissue samples and, along with p14 ARF, is localized to the perinucleolar region within the nucleus.
仕様
Synonyms：Calcium response factor,CARF,CARF,CDKN2A interacting protein,CDKN2A-interacting protein,Cdkn2aip,collaborates/cooperates with ARF （alternate reading frame） protein,Collaborator of ARF,FLJ20036
Host：Rabbit
Reactivity：Human
Applications：IHC,ELISA
Concentration：0.3mg/mL
Immunogen：Recombinant protein of human CDKN2AIP
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：Q9NXV6
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling
