Background：IQGAP3 （IQ motif containing GTPase activating protein 3） is a 1,631 amino acid protein that acts as an effector of Cdc42 and Rac 1, linking their activation to the cytoskeleton during neuronal morphogenesis. A novel member of the IQGAP family, IQGAP3 is highly expressed in brain where it localizes to axons of hippocampal neurons. IQGAP3 contains one Ras-GAP domain, a CH （calponin-homology） domain, four IQ domains and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8％ of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson's disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
仕様
Synonyms：IQ motif containing GTPase activating protein 3,IQGA3,IQGAP 3,IQGAP3,MGC10170,MGC10831,MGC1947,OTTHUMP00000031854,OTTHUMP00000031855,Ras GTPase activating like protein IQGAP3,Ras GTPase-activating-like protein IQGAP3
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,ELISA
Concentration：0.3mg/mL
Immunogen：Recombinant protein of human IQGAP3
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
