Background：This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex （CENP-NAC） and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.
仕様
Synonyms：Beta 3 endonexin,Beta3 endonexin,Beta3 endonexin long form,CENP R,CENPR,CENPR,Centromere protein R,endonexin,Beta-3,HSU37139,Integrin beta 3 binding protein （beta3-endonexin）,Integrin beta 3 binding protein,NRIF 3,NRIF3,Nuclear receptor interacting factor 3,TAP 20,TAP20
Host：Rabbit
Reactivity：Human
Applications：IHC,ELISA
Concentration：0.7mg/mL
Immunogen：Recombinant protein of human ITGB3BP
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：Q13352
Isotype：IgG
Research Areas：Epigenetics and Nuclear Signaling, Signal transduction
