Background：The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein （APP）. Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene.
仕様
Synonyms：Amyloid precursor protein secretase,APP secretase,APPS,CATB,Cathepsin B heavy chain,Cathepsin B1,CathepsinB,CPSB,CTSB,cysteine protease,OTTHUMP00000116009,OTTHUMP00000229510,OTTHUMP00000229511,OTTHUMP00000229512,OTTHUMP00000229514,OTTHUMP00000229515,OTTHUMP00000229516,Preprocathepsin B
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.8mg/mL
Immunogen：Recombinant protein of human CTSB
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：150-1：500
Swissprot：P07858
Isotype：IgG
Research Areas：Cancer, Neuroscience, Signal transduction
