Background：This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
仕様
Synonyms：AMPH 2,AMPH2,Amphiphysin 2,Amphiphysin II,Amphiphysin like protein,amphiphysin-like,Amphiphysin-like protein,AMPHL,Bin1,BIN1,Box Dependant MYC Interacting Protein 1,Box-dependent myc-interacting protein 1,Bridging integrator 1,DKFZp547F068,MGC10367,MGC105358,Myc box dependent interacting protein 1,Myc box-dependent-interacting protein 1,SH3P9
Host：Rabbit
Reactivity：Human
Applications：WB,ELISA
Concentration：0.1mg/mL
Immunogen：Recombinant protein of human BIN1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：200-1：1000
Swissprot：O00499
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Microbiology
