Background：This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen （COL1A1） reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
仕様
Synonyms：Alpha 2 collagen type I,Alpha 2 type I collagen,Alpha 2 type I procollagen,Alpha 2（I） collagen,Alpha 2（I） procollagen,Alpha-2 type I collagen,CO1A2,COL1A2,Collagen alpha 2（I） chain,Collagen alpha-2（I） chain,Collagen I alpha 2 polypeptide,Collagen of skin tendon and bone alpha 2 chain,Collagen type I alpha 2,OI4,Osteogenesis imperfecta type IV,Type I procollagen
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.1mg/mL
Immunogen：Recombinant protein of human COL1A2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：100-1：300
Swissprot：P08123
Isotype：IgG
Research Areas：Cancer, Signal transduction, Stem cells
