Background：The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.
仕様
Synonyms：I kappa B related protein,I-kappa-B-related protein,IkappaBR,IKBR,Inhibitor of kappa B related protein,Inhibitor of kappa B-related protein,MMS22L-interacting protein,MMS22L-interacting protein,NFBIL2/TONSL,NF kappa B inhibitor like protein 2,NF-kappa-B inhibitor-like protein 2,NFBIL2,NFBIL2/TONSL,Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like protein 2,Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2,Protein IkappaBR,Tonsl,TONSL,Tonsoku-like protein,tonsoku-like,DNA repair protein
Host：Rabbit
Reactivity：Human
Applications：IHC,ELISA
Concentration：0.6mg/mL
Immunogen：Recombinant protein of human TONSL
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：100-1：300
Swissprot：Q96HA7
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Signal transduction
