Background：The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. NFKBIE protein expression is up-regulated following NF-kappaB activation and during myelopoiesis. NFKBIE is able to inhibit NF-kappaB-directed transactivation via cytoplasmic retention of REL proteins. NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-kappaB transcription factor complex. The NF-kappaB complex is inhibited by I-kappa-B proteins （NFKBIA or NFKBIB）, which inactivate NF-kappa-B by trapping it in the cytoplasm.
仕様
Synonyms：I kappa B epsilon,I-kappa-B-epsilon,IkappaBepsilon,IkB E,IkB-E,IkB-epsilon,IKBE,IKBE,MGC72568,NF kappa B inhibitor epsilon,NF kappa BIE,NF-kappa-B inhibitor epsilon,NF-kappa-BIE,NFkappa BIE,NFkappaB inhibitor epsilon,NFKBIE,Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor epsilon,OTTHUMP00000016522,Slc35b2,solute carrier family 35,member B2
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC,ELISA
Concentration：0.3mg/mL
Immunogen：Recombinant protein of human NFKBIE
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：200-1：1000, IHC 1：50-1：200
Swissprot：O00221
Isotype：IgG
Research Areas：Epigenetics and Nuclear Signaling, Immunology, Signal transduction
