Background：This gene encodes a member of the cysteine-aspartic acid protease （caspase） family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.
仕様
Synonyms：Apoptosis related cysteine protease,CASP 14,CASP-14,CASP14,Caspase 14 apoptosis related cysteine protease,Caspase 14 precursor,Caspase-14 subunit p10,Caspase14,CASPE,MGC119078,MGC119079,MICE,Mini ICE
Host：Rabbit
Reactivity：Human
Applications：WB,ELISA
Concentration：0.7mg/mL
Immunogen：Recombinant protein of human CASP14
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
