Background：PCP-4 （Purkinje cell protein 4）, also known as PEP-19, is a calmodulin （CaM） regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C （PKC）. PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer's disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.
仕様
Synonyms：Brain specific antigen PCP 4,Brain specific polypeptide PEP 19,Brain specific polypeptide PEP19,Brain-specific antigen PCP-4,Brain-specific polypeptide PEP-19,OTTHUMP00000109191,Pcp4,PCP4,PEP19,Purkinje cell protein 4
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC,ELISA
Concentration：1mg/mL
Immunogen：Recombinant protein of human PCP4
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
