Background：The activated kinase acts on a variety of targets. Phosphorylates ribosomal protein S6, histone H4 and myelin basic protein. Full length PAK 2 stimulates cell survival and cell growth. The process is, at least in part, mediated by phosphorylation and inhibition of pro-apoptotic BAD. Caspase-activated PAK-2p34 is involved in cell death response, probably involving the JNK signaling pathway. Cleaved PAK-2p34 seems to have a higher activity than the CDC42-activated form.
仕様
Synonyms：C-t-PAK2,CB422,EC 2.7.11.1,Gamma PAK,Gamma-PAK,hPAK65,Kinase,p21 （CDKN1A） activated kinase 2,p21 （CDKN1A）-activated kinase 2a,p21 activated kinase 2,p21 protein （Cdc42/Rac）-activated kinase 2,p21 protein Cdc42 Rac activated kinase 2,p21-activated kinase 2,p21-activated kinase,65-KD,p21-activated protein kinase I,p21CDKN1A activated kinase 2,p27,p34,p58,p65PAK,PAK 2,PAK-2,PAK-2p34,Pak2,PAK2,PAK65,PAKgamma,S6 H4 kinase,S6/H4 kinase,Serine threonine protein kinase PAK 2,Serine/threonine protein kinase PAK 2
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human PAKgamma around the non-phosphorylation site of S20.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,0.5％ BSA and 50％ glycerol pH 7.4.
