Background：Natural killer （NK） cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent （C-type） lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation （has an extracellular C terminus） and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 （killer cell lectin-like receptor subfamily C, member 4） family member in the same cluster.
仕様
Synonyms：CD314,CD314 antigen,D12S2489E,Killer cell lectin like receptor subfamily K member 1,Killer cell lectin-like receptor subfamily K member 1,KLR,KLRC4 KLRK1 readthrough,KLRK1,NK cell receptor D,NK lectin-like receptor,NKG2 D activating NK receptor,NKG2 D type II integral membrane protein,NKG2-D,NKG2-D type II integral membrane protein,NKG2-D-activating NK receptor,Nkg2d,NKG2D,NKLLR,NKR P2,Nkrp2
Host：Rabbit
Reactivity：Human
Applications：WB,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the Internal region of human CD314
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,0.5％ BSA and 50％ glycerol pH 7.4.
