Background：This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98％ amino acid sequence identity with the mouse ortholog. DiGeorge syndrome （DGS）/velocardiofacial syndrome （VCFS）, a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
仕様
Synonyms：Brachyury,CAFS,CTHM,DGCR,DGS,DORV,T box,T box 1,T box 1 transcription factor,T box 1 transcription factor C,T box protein 1,T box transcription factor TBX 1,T box transcription factor TBX1,T-box protein 1,T-box transcription factor TBX1,TBX 1,TBX 1C,tbx1,TBX1,TBX1C,Testis specific T box protein,Testis-specific T-box protein,TGA,VCFS
Host：Rabbit
Reactivity：Human
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the C-terminal region of human TBX1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,0.5％ BSA and 50％ glycerol pH 7.4.
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：20000
Gene_ID（human）：6899
Swissprot：O43435
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Neuroscience
