Background：cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex （CNC）. This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence （NLS） has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C （RFC40）. Several alternatively spliced transcript variants encoding two different isoforms have been observed.
仕様
Synonyms：ACRDYS1,ADOHR,cAMP dependent protein kinase regulatory subunit alpha 1,cAMP dependent protein kinase regulatory subunit RIalpha,cAMP dependent protein kinase type I alpha regulatory chain,cAMP dependent protein kinase type I alpha regulatory subunit,cAMP-dependent protein kinase type I-alpha regulatory subunit,CAR,Carney complex type 1,CNC 1,CNC,CNC1,DKFZp779L0468,KAP0,MGC17251,PKA RIA,PKR 1,PKR1,PPNAD 1,PPNAD1,PRKAR 1,PRKAR1,PRKAR1A,PRKAR1A/RARA FUSION GENE,Protein kinase A type 1a regulatory subunit,Protein kinase cAMP dependent regulatory type I alpha,PTC2 CHIMERIC ONCOGENE,INCLUDED,Tissue specific extinguisher 1,Tissue-specific extinguisher 1,TSE 1,TSE1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the C-terminal region of human PKA Ia reg
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,0.5％ BSA and 50％ glycerol pH 7.4.
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：20000
Gene_ID（human）：5573
Swissprot：P10644
Isotype：IgG
Research Areas：Cancer, Metabolism, Signal transduction
