Background：This gene is a member of the Src family of protein tyrosine kinases （PTKs）. The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described.
仕様
Synonyms：IMD22,LCK,Lck p56,LCK proto-oncogene,Src family tyrosine kinase,LCK,Leukocyte C-terminal Src kinase,LSK,Lymphocyte cell specific protein tyrosine kinase,Lymphocyte cell-specific protein-tyrosine kinase,Lymphocyte specific protein tyrosine kinase,Membrane associated protein tyrosine kinase,Oncogene lck,P56 LCK,p56（LSTRA） protein tyrosine kinase,p56-LCK,p56lck,pp58 lck,pp58lck,Protein YT16,Proto oncogene tyrosine protein kinase LCK,Proto-oncogene Lck,Protooncogene tyrosine protein kinase LCK,T cell specific protein tyrosine kinase,T cell-specific protein-tyrosine kinase,T lymphocyte specific protein tyrosine kinase p56lck,Tyrosine-protein kinase Lck,YT 16,YT16
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human Lck around the non-phosphorylation site of S540.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,0.5％ BSA and 50％ glycerol pH 7.4.
Dilution：WB 1：500-1：2000, ELISA 1：40000
Gene_ID（human）：3932
Swissprot：P06239
Isotype：IgG
Research Areas：Cancer, Immunology, Signal transduction
