Background：The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V（D）J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V（D）J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
仕様
Synonyms：86 kDa subunit of Ku antigen,ATP dependent DNA helicase 2 subunit 2,ATP dependent DNA helicase II 80 kDa subunit,ATP dependent DNA helicase II 86 Kd subunit,ATP dependent DNA helicase II,ATP-dependent DNA helicase 2 subunit 2,ATP-dependent DNA helicase II 80 kDa subunit,CTC box binding factor 85 kDa,CTC box-binding factor 85 kDa subunit,CTC85,CTCBF,DNA repair protein XRCC5,KARP 1,KARP1,Ku 80,Ku autoantigen 80kDa,Ku80,Ku86,Ku86 autoantigen related protein 1,KUB 2,KUB2,Lupus Ku autoantigen protein p86,NFIV,Nuclear factor IV,Thyroid lupus autoantigen,Thyroid-lupus autoantigen,TLAA,X ray repair complementing defective repair in Chinese hamster cells 5 （double strand break rejoining）,X-ray repair complementing defective repair in Chinese hamster cells 5 （double-strand-break rejoining）,X-ray repair cross-complementing protein 5,Xray repair complementing defective repair in Chinese hamster cells 5,XRCC 5,XRCC5,XRCC5
Host：Rabbit
Reactivity：Human,Monkey
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the C-terminal region of human Ku-80
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,0.5％ BSA and 50％ glycerol pH 7.4.
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：20000
Gene_ID（human）：7520
Swissprot：P13010
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
