Background：This gene belongs to the TBR1 （T-box brain protein 1） sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants.EOMES （Eomesodermin） is a Protein Coding gene. Diseases associated with EOMES include Microcephaly-Polymicrogyria-Corpus Callosum Agenesis Syndrome and Microcephaly With Polymicrogyria. Among its related pathways are Mesodermal Commitment Pathway and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is TBR1.
仕様
Synonyms：eomes,EOMES,Eomesodermin,Eomesodermin homolog,t box brain 2,T-box brain protein 2,T-brain-2,Tbr 2,TBR-2
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the N-terminal region of human EOMES.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,0.5％ BSA and 50％ glycerol pH 7.4.
Dilution：WB 1：500-1：2000, ELISA 1：10000
Gene_ID（human）：8320
Swissprot：O95936
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Developmental biology, Neuroscience, Stem cells
