Background：The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V（D）J recombination and DNA double-strand break （DSB） repair through nonhomologous end joining （NHEJ）. This protein forms a complex with the X-ray repair cross complementing protein 4 （XRCC4）, and further interacts with the DNA-dependent protein kinase （DNA-PK）. Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.
仕様
Synonyms：DNA ligase IV ATP dependent,DNA joinase,DNA ligase 4,DNA ligase IV,DNA repair enzyme,DNLI4,LIG 4,LIG4,LIG4S,Ligase IV,Ligase IV DNA ATP dependent,Polydeoxyribonucleotide synthase [ATP] 4,Polydeoxyribonucleotide synthase 4,Polydeoxyribonucleotide synthase,Polynucleotide ligase,Sealase
Host：Rabbit
Reactivity：Human
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the Internal region of human DNA Ligase IV
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,0.5％ BSA and 50％ glycerol pH 7.4.
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：20000
Gene_ID（human）：3981
Swissprot：P49917
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
