Background：This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t（10;11） chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14
仕様
Synonyms：Abelson interactor 1,Abi-1,Abi1,ABI1,Abl binding protein 4,Abl interactor 1,Abl interactor protein 1,Abl-binding protein 4,AblBP4,e3B1,Eps8 binding protein,Eps8 SH3 domain binding protein,Eps8 SH3 domain-binding protein,Eps8-binding protein,Hssh3bp1,Interactor protein AblBP4,NAP1,Nap1 binding protein,Nap1-binding protein,Nap1BP,Spectrin SH3 domain binding protein 1,Spectrin SH3 domain-binding protein 1,SSH3BP
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the Internal region of human Abi-1.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,0.5％ BSA and 50％ glycerol pH 7.4.
