Background：GLI1 （GLI Family Zinc Finger 1） is a Protein Coding gene. Diseases associated with GLI1 include Basal Cell Carcinoma and Necrobiosis Lipoidica. Among its related pathways are Wnt Signaling Pathways： beta-Catenin-independent Wnt/Ca2+ Signaling and Other Non-canonical Wnt Signaling Pathways and G-Beta Gamma Signaling. GO annotations related to this gene include chromatin binding and microtubule binding. An important paralog of this gene is GLI2. This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：Gli 1,GLI,GLI family zinc finger 1,GLI Kruppel family member 1,gli1,GLI1,Glioma associated oncogene 1,Glioma associated oncogene homolog 1 （zinc finger protein）,Glioma associated oncogene homolog,Glioma-associated oncogene,Oncogene GLI,Zfp 5,Zfp5,Zinc finger protein GLI 1,Zinc finger protein GLI1
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human GLI-1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000
Gene_ID（human）：2735
Swissprot：P08151
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Neuroscience, Stem cells
