Background：The protein encoded by this gene is a member of the protein tyrosine phosphatase （PTP） family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling.
仕様
Synonyms：B220,CD 45,CD45,CD45 antigen,CD45R,GP180,L-CA,LCA,Leukocyte common antigen,loc,Ly-5,LY5,Ly5,homolog of,Lyt-4,OTTHUMP00000033813,OTTHUMP00000033816,OTTHUMP00000033817,OTTHUMP00000038574,Protein tyrosine phosphatase receptor type c polypeptide,Protein tyrosine phosphatase,receptor type C,protein tyrosine phosphatase,receptor type,C,Protein tyrosine phosphatase,receptor type,c polypeptide,Ptprc,PTPRC,Receptor-type tyrosine-protein phosphatase C,T200,T200 glycoprotein,T200 leukocyte common antigen
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human CD45 around the non-phosphorylation site of Ser1007.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：5000
Gene_ID（human）：5788
Swissprot：P08575
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Immunology, Neuroscience, Signal transduction, Stem cells
