Background：Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 and -A5. Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly （By similarity）. Induces apoptosis in a p53/TP53-independent, caspase-8-dependent manner.
仕様
Synonyms：ARCC2,AW545284,CTPA,CTPP1,CTRCT6,EC 2.7.10.1,Eck,Eph receptor A2,EPHA2,EPHA2,Ephrin receptor,Ephrin receptor EphA2,Ephrin type A receptor 2,Ephrin type-A receptor 2,Epithelial cell kinase,Epithelial cell receptor protein tyrosine kinase,Myk 2,Myk2,Sek 2,Sek2,Soluble EPHA2 variant 1,Tyrosine protein kinase receptor ECK,Tyrosine-protein kinase receptor ECK,Tyrosine-protein kinase receptor MPK-5,Tyrosine-protein kinase receptor SEK-2
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the N-terminal region of human EphA2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, ELISA 1：40000
Gene_ID（human）：1969
Swissprot：P29317
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Neuroscience
