Background：This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors （GEFs） for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.VAV3 （Vav Guanine Nucleotide Exchange Factor 3） is a Protein Coding gene. Diseases associated with VAV3 include Glaucoma, Normal Tension. Among its related pathways are p75 NTR receptor-mediated signaling and Mesodermal Commitment Pathway. GO annotations related to this gene include GTPase activator activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is VAV1.
