Background：Down regulates expression of stem cell growth factor receptor （KIT）. Acts as an effector of EpoR （erythropoietin receptor） in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation （By similarity）. Acts as a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta-2 integrins. Acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. Involved in induction of stress-activated protein kinase （SAPK）, but not ERK or p38 MAPK, in response to genotoxic agents. Induces SAPK by a MKK7- and MEKK1-dependent mechanism. The LYN -＞ MEKK1 -＞ MKK7 -＞ SAPK pathway is functional in the induction of apoptosis by genotoxic agents.
仕様
Synonyms：AA407514,EC 2.7.10.2,FLJ26625,Hck 2,JTK 8,JTK8,Lck/Yes related novel protein tyrosine kinase,LYN,LYN proto oncogene,Src family tyrosine kinase,LYN,ONCOGENE LYN,p53Lyn,p56Lyn,Tyrosine protein kinase LYN,Tyrosine-protein kinase Lyn,V yes 1 Yamaguchi sarcoma viral related oncogene homolog,Yamaguchi sarcoma viral （v yes 1） related oncogene homolog
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human Lyn around the non-phosphorylation site of Tyr192.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
