Background：This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates.
仕様
Synonyms：58 kDa glucose regulated protein,58 kDa glucose-regulated protein,58 kDa microsomal protein,Disulfide isomerase ER 60,Disulfide isomerase ER-60,Endoplasmic reticulum resident protein 57,Endoplasmic reticulum resident protein 60,ER p57,ER protein 57,ER protein 60,ERp 57,ERp57,ERp60,ERp61,Glucose Regulated Protein 58 Kd,GRP 57,GRP 58,GRP57,HsT17083,p58,PDIA 3,PDIA3,PDIA3,Phospholipase C alpha,PI PLC,Protein disulfide isomerase A3,Protein disulfide isomerase family A member 3,Protein disulfide-isomerase A3
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the Internal region of human ERp57.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
