Background：Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge.
仕様
Synonyms：AIS,Amplified in squamous cell carcinoma,B（p51A）,B（p51B）,Chronic ulcerative stomatitis protein,CUSP,DN p63 alpha 1,DNp63,EEC3,id：ibd3516,Keratinocyte transcription factor,Keratinocyte transcription factor KET,KET,LMS,MGC115972,MGC192897,NBP,OFC8,OTTHUMP00000209732,OTTHUMP00000209733,OTTHUMP00000209734,OTTHUMP00000209735,OTTHUMP00000209737,OTTHUMP00000209738,OTTHUMP00000209739,OTTHUMP00000209740,OTTHUMP00000209741,OTTHUMP00000209742,OTTHUMP00000209743,OTTHUMP00000209744,p40,p51,P51/P63,p53-related protein p63,p53CP,p63,P63,p73H,p73L,RHS,SHFM4,TAp63alpha,TP53CP,TP53L,TP63,TP73L,Transformation related protein 63,Transformation-related protein 63,Trp53rp1,Trp63,Tumor protein 63,Tumor protein p53-competing protein,Tumor protein p53-like,Tumor protein p63,Tumor protein p63 deltaN isoform delta,Tumor protein p73,Tumor protein p73-like
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the N-terminal region of human p63.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
