Background：EEA1 is an early endosomal marker and a Rab5 effector protein essential for early endosomal membrane fusion and trafficking. The carboxy terminus of EEA1 contains a FYVE domain which binds to phosphatidylinositol-3-phosphate （PtdIns（3）P）, targeting EEA1 to early endosomes. The stable association of EEA1 with the endosomal membrane is regulated by PI3 kinase, Rab5 and calcium/calmodulin. Once on the membrane, EEA1 interacts with Rab5, NSF and syntaxin 13 to promote early endosomal membrane docking and fusion.
仕様
Synonyms：Early endosome antigen 1,Early endosome antigen 1,162kD,Early endosome associated protein,EEA 1,EEA1,EEA1,Endosome associated protein p162,Endosome-associated protein p162,MST105,MSTP105,ZFYVE2,Zinc finger FYVE domain containing protein 2,Zinc finger FYVE domain-containing protein 2
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the N-terminal region of human EEA1.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, ELISA 1：20000
Gene_ID（human）：8411
Swissprot：Q15075
Isotype：IgG
Research Areas：Cancer, Neuroscience, Signal transduction, Tags ＆ Cell Markers
