Background：Ubiquitin exists either covalently attached to another protein, or free （unanchored）. When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer （monoubiquitin）, a polymer linked via different Lys residues of the ubiquitin （polyubiquitin chains） or a linear polymer linked via the initiator Met of the ubiquitin （linear polyubiquitin chains）. Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked： Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD （endoplasmic reticulum-associated degradation） and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.
仕様
Synonyms：UBB,Polyubiquitin-B,UBC,Polyubiquitin-C,RPS27A,UBA80,UBCEP1,Ubiquitin-40S ribosomal protein S27a,Ubiquitin carboxyl extension protein 80,UBA52,UBCEP2,Ubiquitin-60S ribosomal protein L40,CEP52,Ubiquitin A-52 residue ribosomal pr
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the Internal region of human Ub
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
