Background：Apoptosis mediated by death factors like FasL and TNF-a involves the formation of a death-inducing signaling complex （DISC） to their respective receptors （1）. Upon ligand activation to their receptors, Fas and TNF-R1 associate with death domain （DD） containing adaptor proteins FADD （Fas associated death domain） （2,3） and TRADD （TNF-R1 associated death domain） （4）. In addition to its carboxy-terminal DD, FADD contains an amino-terminal death effector domain （DED） that binds to DEDs found on caspase-8 which leads to activation of this initiator caspase （5,6）. Caspase-8 subsequently activates downstream effector caspases, like caspase-3, resulting in the cleavage of proteins involved in the execution of apoptosis. Unlike FADD, TRADD does not contain a DED （4）. Apoptosis driven by TNF-R1 binding to TRADD involves association of TRADD and FADD which then leads to activation of caspase-8 （7）.
仕様
Synonyms：9130005N23Rik,AA930854,TNFR1 associated DEATH domain protein,TNFR1-associated DEATH domain protein,TNFRSF1A associated via death domain,TNFRSF1A-associated via death domain,tradd,TRADD,Tumor necrosis factor receptor type 1 associated DEATH domain protein,Tumor necrosis factor receptor type 1-associated DEATH domain protein
Host：Rabbit
Reactivity：Human,Mouse,Monkey
Applications：WB,IHC-p,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the C-terminal region of human TRADD
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
