Background：This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
仕様
Synonyms：CSC 21K,CSC-21K,CSC21K,Metalloproteinase inhibitor 2,Metalloproteinase inhibitor 2 precursor,TIMP 2,TIMP metallopeptidase inhibitor 2,TIMP-2,TIMP2,TIMP2,Tissue Inhibitor of Metalloproteinase 2,Tissue inhibitor of metalloproteinases 2
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the Internal region of human TIMP-2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：40000
Gene_ID（human）：7077
Swissprot：P16035
Isotype：IgG
Research Areas：Cancer, Cell Biology, Cardiovascular, Signal transduction
