Background：This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases （MMPs）, a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
仕様
Synonyms：Clgi,Collagenase inhibitor,Collagenase inhibitor,Human,EPA,EPO,Erythroid Potentiating Activity,Erythroid-potentiating activity,Fibroblast collagenase inhibitor,FLJ90373,HCI,Human Collagenase Inhibitor,Metalloproteinase inhibitor 1,Metalloproteinase inhibitor 1 precursor,OTTHUMP00000023214,TIMP 1,TIMP,TIMP metallopeptidase inhibitor 1,TIMP-1,Timp1,TIMP1 protein,TIMP1,Tissue Inhibitor of Metalloproteinase 1,Tissue inhibitor of metalloproteinases 1,Tissue inhibitor of metalloproteinases,Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the Internal region of human TIMP-1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：50-1：200, IF 1：50-1：200, ELISA 1：10000
Gene_ID（human）：7076
Swissprot：P01033
Isotype：IgG
Research Areas：Cancer, Cell Biology, Cardiovascular, Signal transduction
