Background：Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1（I） collagen, LCK, IL-3 and GM-CSF promoters （By similarity）. Inhibits MYST4-dependent transcriptional activation.
仕様
Synonyms：Acute myeloid leukemia 3 protein,Alpha subunit 1,AML3,CBF alpha 1,CBF-alpha-1,CBFA1,CCD,CCD1,Cleidocranial dysplasia 1,Core binding factor,Core binding factor runt domain alpha subunit 1,Core binding factor subunit alpha 1,Core-binding factor subunit alpha-1,MGC120022,MGC120023,Oncogene AML 3,Oncogene AML-3,OSF 2,OSF-2,OSF2,Osteoblast specific transcription factor 2,Osteoblast-specific transcription factor 2,OTTHUMP00000016533,PEA2 alpha A,PEA2-alpha A,PEA2aA,PEBP2 alpha A,PEBP2-alpha A,PEBP2A1,PEBP2A2,PEBP2aA,PEBP2aA1,Polyomavirus enhancer binding protein 2 alpha A subunit,Polyomavirus enhancer-binding protein 2 alpha A subunit,Runt domain,Runt related transcription factor 2,Runt-related transcription factor 2,RUNX2,RUNX2,SL3 3 enhancer factor 1 alpha A subunit,SL3-3 enhancer factor 1 alpha A subunit,SL3/AKV core binding factor alpha A subunit,SL3/AKV core-binding factor alpha A subunit
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC-p,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the Internal region of human RUNX2.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
