Background：This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
仕様
Synonyms： coiled-coil-containing protein kinase 1,coiled-coil-containing protein kinase I,MGC131603,MGC43611,p160 Rhoassociated coiled coil-forming protein kinase,p160 ROCK-1,p160 ROCK1,p160ROCK,PRO0435,Renal carcinoma antigen NY REN 35,Renal carcinoma antigen NY-REN-35,Rho associated coiled coil containing protein kinase 1,Rho associated protein kinase 1,Rho kinase,Rho-alpha kinase,Rho-associated,Rho-associated protein kinase 1,ROCK I,ROCK-I,ROCK1,ROCK1,Rok,rokalpha
Host：Rabbit
Reactivity：Human,Mouse,Rat,Monkey
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the Internal region of human Rock-1.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, ICC 1：200-1：1000, IF 1：50-1：200, ELISA 1：10000-1：20000
Gene_ID（human）：6093
Swissprot：Q13464
Isotype：IgG
Research Areas：Cancer, Cell Biology, Signal transduction
