Background：This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：BBC 3,Bbc3,BBC3,BCL 2 binding component 3,Bcl-2-binding component 3,BCL2 binding component 3,JFY 1,JFY-1,JFY1,p53 up regulated modulator of apoptosis,p53 up-regulated modulator of apoptosis,p53 Upregulated Modulator of Apoptosis,PUMA alpha,PUMA/JFY1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the C-terminal region of human PUMA.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, ELISA 1：10000
Gene_ID（human）：27113
Swissprot：Q9BXH1
Isotype：IgG
Research Areas：Cancer, Cell Biology, Metabolism, Signal transduction
