Background：The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B （PRB） is involved activation of c-SRC/MAPK signaling on hormone stimulation.Isoform A： inactive in stimulating c-Src/MAPK signaling on hormone stimulation.Isoform 4： Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
仕様
Synonyms：NR3C3,Nuclear receptor subfamily 3 group C member 3,PGR,PR,PRA,PRB,PRGR,Progesterone receptor,Progestin receptor form A,Progestin receptor form B
Host：Rabbit
Reactivity：Human
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human PR around the non-phosphorylation site of Ser400.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：5000
Gene_ID（human）：5241
Swissprot：P06401
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Neuroscience, Signal transduction
