Background：The protein encoded by this gene is a member of the tripartite motif （TRIM） family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia （APL）. Extensive alternative splicing of this gene results in several variations of the protein＆apos;s central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
仕様
Synonyms：Acure promyelocytic leukemia,inducer of,MYL,Pml,PML,PP8675,Probable transcription factor PML,Promyelocytic leukemia,Promyelocytic leukemia inducer of,Promyelocytic leukemia protein,Protein PML,RING finger protein 71,RNF 71,RNF71,TRIM 19,Tripartite motif protein TRIM19,Tripartite motif-containing protein 19
Host：Rabbit
Reactivity：Human
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the N-terminal region of human PML
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：10000
Gene_ID（human）：5371
Swissprot：P29590
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Metabolism
