Background：Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate （PEP） to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
仕様
Synonyms：CTHBP,Cytosolic thyroid hormone binding protein,Cytosolic thyroid hormone-binding protein,KPYM,MGC3932,OIP 3,OIP-3,OIP3,OPA interacting protein 3,Opa-interacting protein 3,p58,PK muscle type,PK,muscle type,PK2,PK3,PKM,PKM2,pykm,Pyruvate kinase 2/3,Pyruvate kinase 3,Pyruvate kinase isozymes M1/M2,Pyruvate kinase muscle,Pyruvate kinase muscle isozyme,pyruvate kinase PKM,Pyruvate kinase,muscle 2,TCB,THBP1,Thyroid hormone binding protein 1,Thyroid hormone binding protein cytosolic,Thyroid hormone-binding protein 1,Tumor M2 PK,Tumor M2-PK
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the Internal region of human PKM2.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-2000, IHC 1：50-300, IF 1：50-1：200, ELISA 1：10000-20000
Gene_ID（human）：5315
Swissprot：P14618
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
