Background：Members of the protein kinase C （PKC） family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols （DAG） and tumor promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into many different isoforms （a, bI, bII, gamma, delta, epsilon, ζ, η, theta, ι, λ, and ν）. Patterns of expression for each PKC isoform differ among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance,the kinase activities of PKC delta and epsilon are independent of Ca2+. On the other hand, most of the other PKC members possess phorbol ester-binding activities and kinase activities.
仕様
Synonyms：PRKCA,PKCA,PRKACA,Protein kinase C alpha type,PKC-A,PKC-alpha,PRKCB,PKCB,PRKCB1,Protein kinase C beta type,PKC-B,PKC-beta,PRKCD,Protein kinase C delta type,Tyrosine-protein kinase PRKCD,nPKC-delta,PRKCE,PKCE,Protein kinase
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human PKC around the non-phosphorylation site of Thr497.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：5000
