Background：PRKACA encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. The protein encoded by PRKACB is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP （cyclic AMP）-dependent protein kinase, which mediates signaling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.Cyclic AMP-dependent protein kinase （PKA） consists of two catalytic subunits and a regulatory subunit dimer.
仕様
Synonyms：PRKACA,PKACA,cAMP-dependent protein kinase catalytic subunit alpha,PKA C-alpha,PRKACB,cAMP-dependent protein kinase catalytic subunit beta,PKA C-beta,PRKACG,cAMP-dependent protein kinase catalytic subunit gamma,PKA C-gamma
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human PKAa/b/gamma cat around the non-phosphorylation site of Thr198.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：20000
Gene_ID（human）：5566/5567
Swissprot：P17612,P22694,P22612
Isotype：IgG
Research Areas：Cancer, Metabolism, Signal transduction
